Endoxifen HCl( Z-Endoxifen HCl | Z Endoxifen HCl | ZEndoxifen Hydrochloride )

Catalog No. M17762 CAS No. 1032008-74-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Endoxifen HCl
Note

Research use only, not for human use.
Brief Description

Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
Description

Z-Endoxifen HCl is an estrogen receptor alpha (ERalpha) ligand, potent antiestrogen, and metabolite of tamoxifen. Z-endoxifen is the most potent of the metabolites of tamoxifen, and has the potential to be more effective than tamoxifen because it bypasses potential drug resistance mechanisms attributable to patient variability in the expression of the hepatic microsomal enzyme CYP2D6.
In Vitro

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In Vivo

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Synonyms

Z-Endoxifen HCl | Z Endoxifen HCl | ZEndoxifen Hydrochloride
Pathway

Membrane Transporter/Ion Channel
Target

Sodium Channel
Recptor

ER
Research Area

Cancer
Indication

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CAS Number

1032008-74-4
Formula Weight

409.95
Molecular Formula

C25H28ClNO2
Purity

>98% (HPLC)
Solubility

DMSO : 12.5 mg/mL 30.49 mM; H2O : < 0.1 mg/mL
SMILES

CC/C(=C(\c1ccc(cc1)O)/c1ccc(cc1)OCCNC)/c1ccccc1.Cl
Chemical Name

4-[(Z)-1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol hydrochloride

1. Chae YJ, et al. Endoxifen, the active metabolite of tamoxifen, inhibits cloned hERG potassium channels. Eur J Pharmacol. 2015 Apr 5;752:1-7.

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